For any syringe pump, the key to achieving the most accurate and repeatable dispenses is eliminating all air from the fluid path. Traditional syringes trap approximately 50 μL of air between the tip of the syringe and the valve. For small volume syringes, this trapped air is the last to leave the syringe and the first to be drawn back in, making them difficult to prime. The Bubble Free Prime syringe features a conical plunger tip which extends through the threaded termination of the syringe and into the valve. This unique design expels the air from the syringe and valve decreasing the number of cycles required to prime the fluid path.